Download Alzheimer’s Disease: Lessons from Cell Biology by E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., PDF

By E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., D. J. Selkoe M.D., Y. Christen Ph.D. (eds.)

Like the unflinching gaze of Captain Ahab strolling the deck of the Pequod, Alzheimer researchers have had their attractions mounted firmly at the illness for a few years. Now, as this quantity amply demonstrates, entire researchers from different fields, who've idea deeply approximately mobilephone organic difficulties are utilising their insights to Alzheimer's disorder. The contri­ butions the following signify the textual content types of the complaints from the 10th "Colloque medecine et recherche" of the Fondation IPSEN dedicated to examine on Alzheimer's disorder. The symposium, entitled "Alzheimer's ailment: classes from mobile Biology" used to be held in Paris on April 25, 1994. As is clear from the numerous backgrounds of the members, the clinical pursuit of Alzheimer's affliction has began to meld with extra easy disciplines, rather phone biology. whereas at the one hand, new parts of specialization are continually rising, the limits of older disciplines are increas­ ingly blurred. probably for many of the years because the first descriptions of the ailment in 1907, the technological know-how of Alzheimer's affliction used to be descriptive, and lay within the province of pathologists. this period of time, in which greatly was once discovered in regards to the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of those hallmark buildings. the fashionable period of Alzheimer's affliction learn opened with the iden­ tification of the part proteins in plaques and tangles.

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Extra resources for Alzheimer’s Disease: Lessons from Cell Biology

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2. Basolateral targeting motifs in the LDL receptor cytoplasmic domain. (Taken from Matter et al. , in preparation). At present, however, the motif is too degenerate and the number of examples are too few to determine if this is indeed the case. In addition, it is clearly the case that some basolateral signals exist that are distinct from those defined in LDL receptor. For example, the polymeric immunoglobulin receptor, which is responsible for trans-epithelial transport of secretory IgA and IgM, contains an incompletely characterized signal which is nevertheless clearly tyrosine-independent.

3. Pathways of sorting and transport in the trans-Golgi network (TGN). (Taken from a figure to be published in Current Opinion in Cell Biology) Mechanisms of Molecular Sorting in Polarized Cells: Relevance to Alzheimer's Disease 21 known to reach the apical surface (Wandinger-Ness and Simons 1990; Zurzolo et al. 1994). Understanding the mechanism of sorting, the nature of the coat proteins that may be involved, and the features that distinguish apical and basolateral transport vesicles represents the major problems for future research.

Alzheimer's precursor protein (APP) is a type I membrane protein expressed by a variety of polarized cell types, including neurons and cells of epithelial origin. Irrespective of which cell type is the most relevant for the production of amyloidogenic AfJ peptide, the polarity of peptide release is likely to be an important factor in the pathogenesis of the disease. Moreover, knowing the cellular distribution of APP itself may provide some insight into the actual function of this protein, even separate from its role in pathogenesis.

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