By Lena M. Napolitano MD, Krishnan Raghavendran MD
This factor of severe Care Clinics will specialize in serious Acute breathing misery Syndrome and working with it within the ICU. themes will comprise: demanding situations and Successes in ARDS Research;Mechanical air flow with Lung protecting concepts: What works?; Gene remedy for ALI/ARDS;High Frequency Oscillatory air flow in ALI/ARDS;Prone positioning remedy in ARDS;Recovery and long term final result in ARDS; and Experimental types and emergeing hypotheses for ALI and ARDS
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Extra resources for ALI and ARDS: Challenges and Advances, An Issue of Critical Care Clinics (The Clinics: Internal Medicine)
The lower tidal volume 461 462 Thompson & Bernard Fig. 2. Lower tidal volume/higher PEEP reference card for ARMA and ALVEOLI studies. 2 LATE STEROID RESCUE STUDY: LASRS Study status: Completed. Study dates: August 1997 to November 2003. The late phase of ARDS is often characterized by excessive fibroproliferation leading to gas exchange and compliance abnormalities. Although corticosteroids are not effective in early ARDS, several case reports and uncontrolled case series and one small randomized, controlled trial suggest that corticosteroids may be useful in the management of late-phase ARDS.
89. Nuckton TJ, Alonso JA, Kallet RH, et al. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 2002; 346(17):1281–6. 90. Lucangelo U, Bernabe F, Vatua S, et al. Prognostic value of different dead space indices in mechanically ventilated patients with acute lung injury and ARDS. Chest 2008;133(1):62–71. 455 456 Blank & Napolitano 91. Siddiki H, Kojicic M, Li G, et al. Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials.
Connors AF Jr, Speroff T, Dawson NV, et al. The effectiveness of right heart catheterization in the initial care of critically ill patients. JAMA 1996;276:889–97. 8. Bernard GR, Sopko G, Cerra F, et al. Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration workshop report. Consensus statement. JAMA 2000;283(19):2568–72. 9. Wiedemann HP, Wheeler AP, Bernard GR, et al; The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network.